Topical products, such as creams or gels, are sometimes used to treat cold sores. Many are prescription medicines that may slightly shorten the duration of cold sores, usually by just 1 to 2 days.footnote 1
Some experts find that even when non-prescription topical products are used frequently-every 2 hours while a person is awake-at the first sign of an outbreak, they may only speed recovery time by a few hours or a day.footnote 2
Penciclovir cream may cause side effects such as mild pain or stinging when it is applied. It is possible, although rare, that the cream may also cause a skin rash or headache.
Acyclovir ointment or cream works best if it is used at the first sign of cold sore symptoms. Side effects of the ointment may include mild pain or stinging at the site where it is applied.
Acyclovir cream can be used to treat recurrent cold sores in people older than age 12. The cream can improve healing time by up to half a day. The cream may cause temporary skin irritation.
Topical pain medicines can relieve the pain and itching of cold sores. Some examples are benzocaine (Anbesol, Orajel) and camphorated phenol (Polysporin Lip Therapy). Be safe with medicines. Follow the directions on the package. Do not use benzocaine for children younger than 2. It can harm your child.
Docosanol 10% (Abreva) should be applied at the first signs of a cold sore outbreak. It can shorten healing time and the duration of symptoms.
Benzyl alcohol (Zilactin) is a gel that relieves the pain of cold sores and may help shorten healing time, especially if it is used as soon as a cold sore begins to form.
Dimethicone with sunscreen (Blistex) is a product that moisturizes your lips and protects them from the sun. This can help reduce the pain and itching of cold sores. It may also help prevent cold sores from returning.
Cold sores usually heal on their own without prescription medicines or complementary therapies.
Worrall G (2009). Herpes labialis, search date February 2009. Online version of BMJ Clinical Evidence: http://www.clinicalevidence.com.
Habif TP (2010). Warts, herpes simplex, and other viral infections. In Clinical Dermatology, A Color Guide to Diagnosis and Therapy, 5th ed., pp. 454–490. Edinburgh: Mosby Elsevier.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineAnne C. Poinier, MD - Internal MedicineAdam Husney, MD - Family MedicineSpecialist Medical ReviewerThomas M. Bailey, MD - Family Medicine
Current as ofMarch 20, 2017
Current as of: March 20, 2017
E. Gregory Thompson, MD - Internal Medicine
& Anne C. Poinier, MD - Internal Medicine & Adam Husney, MD - Family Medicine & Thomas M. Bailey, MD - Family Medicine
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