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COVID-19 vaccine – protein-based (age 12 years and older)

Learn about the vaccine, doses, side effects, and safety.

COVID-19 protein-based vaccine

COVID-19 vaccines help protect you from getting very sick from COVID-19 and needing care in the hospital.

The Nuvaxovid XFG COVID-19 vaccine is a protein-based vaccine that is approved by Health Canada.

It is an updated protein-based vaccine that helps protect you against the COVID-19 strains that are currently spreading.

Who can get this vaccine

Albertans at high risk

Nuvaxovid COVID-19 vaccine is available free of charge for:

  • People age 65 years and older.
  • People age 12 to 64 years who are at higher risk of severe illness or more likely to be exposed to COVID-19 and spread it to others.

Visit Respiratory virus season – Get vaccinated for details about COVID-19 eligibility.

All other Albertans

All other Albertans age 12 to 64 years who cannot get COVID-19 vaccine free of charge may be able to purchase it at a participating pharmacy.

Who may not be able to get this vaccine

You may not be able to get Nuvaxovid COVID-19 vaccine if:

  • You have an allergy to any part of the vaccine. Be sure to tell your healthcare provider about any allergies you may have.
  • You had a severe (serious) or unusual side effect after this vaccine or one like it.

If any of these apply, check with your healthcare provider before you get the vaccine.

The Nuvaxovid COVID-19 vaccine is not approved for people under age 12 years.

Although you can get the vaccine if you have a mild illness, such as a cold or fever, it is best to stay home until you feel better. This helps prevent spreading your illness to others.

Be sure to talk to your healthcare provider to find out when to get the Nuvaxovid COVID-19 vaccine if:

  • You have a history of multisystem inflammatory syndrome as a child (MIS-C) or an adult (MIS-A).
  • You have a weakened immune system (because of a medicine you take or a health problem).
  • You have had a stem cell or organ transplant.
  • You are getting CAR T-cell therapy (a type of cancer treatment).
  • You have a history of myocarditis, pericarditis, or both within 6 weeks of getting a dose of COVID-19 vaccine.

Already had COVID-19

If you have already had COVID-19, it is not yet known how long your protection will last or how much protection you will have against variants. It is important to get a COVID-19 vaccine even if you have already had the virus.

If you had COVID-19, you can get the vaccine once you are no longer sick and are feeling better.

If you developed multisystem inflammatory syndrome (MIS-C or MIS-A) after having COVID-19, check with your healthcare provider about when to get a COVID-19 vaccine.

Pregnancy and breastfeeding

While you are pregnant, you have a higher risk of getting very sick from COVID-19. Getting a COVID-19 vaccine lowers your risk of getting seriously ill from the virus.

Nuvaxovid COVID-19 vaccine may be an option if you cannot get an mRNA vaccine or you prefer a protein-based vaccine. However, there is more safety information about mRNA COVID-19 vaccines during pregnancy than about Nuvaxovid COVID-19 vaccine.

You can get Nuvaxovid COVID-19 vaccine if you are breastfeeding/chestfeeding.

If you are pregnant or breastfeeding/chestfeeding and have questions about getting any COVID-19 vaccine, talk to your healthcare provider.

Vaccines

If you are age 12 years or older, Nuvaxovid COVID-19 vaccine may be an option if you cannot get an mRNA vaccine or you prefer a protein-based vaccine.

Doses

COVID-19 vaccine recommendations, including how many doses to get, depend on your age and your immune system. Talk to your healthcare provider about what is right for you.

Healthy immune system

If you are age 12 years or older and have not had any COVID-19 vaccines, you need 1 dose of Nuvaxovid XFG COVID-19 vaccine.

If you have already had 1 or more doses of a non-XFG COVID-19 vaccine, you can get 1 dose of the Nuvaxovid XFG COVID-19 vaccine at least 3 months after your last dose of any COVID-19 vaccine.

Weakened immune system

If you are age 12 years or older with a weakened immune system, you need 3 doses of COVID-19 vaccine. The Nuvaxovid XFG COVID-19 vaccine can start or complete your 3-dose series.

If you have already had 3 or more doses of a non-XFG COVID-19 vaccine, you can get 1 dose of the Nuvaxovid XFG COVID-19 vaccine at least 3 months after your last dose of any COVID-19 vaccine.

Off-label use

"Off-label use" means the vaccine is used differently than the way it was originally approved. Vaccine experts support the following off-label uses for Nuvaxovid COVID-19 vaccine and have no safety concerns:

  • You get a dose of Nuvaxovid less than 6 months from a previous dose.
  • You get 3 doses of Nuvaxovid.
  • You have already had 1 dose of a COVID-19 vaccine and get 2 doses of Nuvaxovid.
  • You have not had any COVID-19 vaccines and get 1 dose of Nuvaxovid and do not get a second dose.

Consent for immunization

A parent or guardian must provide consent for a child under age 18 years to get a Nuvaxovid COVID-19 vaccine.

In some cases, children under age 18 years may be able to give their own consent.

Current as of: September 28, 2026
Author: Communicable Disease Control, Primary Care Alberta
Our work takes place on historical and contemporary Indigenous lands, including the territories of Treaty 6, Treaty 7 & Treaty 8 and the homeland of the Métis Nation of Alberta and 8 Métis Settlements. We also acknowledge the many Indigenous communities that have been forged in urban centres across Alberta.