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Peyronie's disease is an abnormal curvature of the penis caused by scar tissue in the erectile tissue. Because the scar tissue prevents straightening of the penis, the curvature is most obvious during an erection. The curvature may be so severe that it prevents penetration during intercourse.
Peyronie's disease usually affects men who are 50 and older.
Although the exact cause of Peyronie's disease is unknown, some experts believe the scarring is caused by injury to the penis from accidents, sports, or vigorous sex. During sexual intercourse, the penis can be injured by being bent during penetration or by pressure from a partner's pubic bone.
Experts also wonder if this disease involves a problem with wound healing.
Peyronie's disease is not caused by cancer and does not increase the risk of cancer. It is not caused by sexually transmitted infections (STIs).
Symptoms of Peyronie's disease may develop slowly or suddenly. Common symptoms include:
Peyronie's disease is usually divided into two stages:
Peyronie's disease is usually diagnosed using a medical history and physical examination. Your doctor will ask you questions about when you first noticed your symptoms and whether the symptoms were gradual or sudden. This will help determine which stage of Peyronie's disease you are experiencing.
Because symptoms of Peyronie's disease are usually most noticeable when the penis is erect, your doctor may inject a drug into your penis to make it erect. This will help your doctor see where the erectile tissue is scarred. Other tests that may be ordered include:
Peyronie's disease rarely gets better on its own. For men who have a slight curve that isn't getting worse and who have good erectile function, treatment usually is not needed. But if pain is a problem, or if the curve is getting worse and interfering with your sexual activity, then getting treatment may help. And early treatment during the acute phase may also work better than waiting until you're in the chronic phase.
Most men are able to remain sexually active. Counselling can help couples maintain an active sexual life.
Medicines may help treat pain and reduce how much the penis curves. They include:
There is not much evidence from studies showing how well any of these medicines work to heal the scarring and reduce the curve.
Surgery is only considered for men who have severe pain, a severely curved penis, or sexual dysfunction related to Peyronie's disease. Surgical options include removing the scar tissue or shortening the unaffected side of the penis (plication). In some cases, use of a penile prosthesis may be used to help keep an erection during intercourse.
Other Works ConsultedMcAninch JW (2008). Disorders of the penis and male urethra. In EA Tanagho, JW McAninch, eds., Smith's General Urology, 17th ed., pp. 625–637. New York: McGraw-Hill Medical.Nehra A, et al. (2015) Peyronie's Disease: AUA Guideline. https://www.auanet.org/education/guidelines/peyronies-disease.cfm. Accessed December 10, 2015.
Current as of: February 10, 2021
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineBrian D. O'Brien MD - Internal MedicineAdam Husney MD - Family MedicineChristopher G. Wood MD, FACS - Urology, Oncology
Current as of: February 10, 2021
Author: Healthwise Staff
Medical Review:E. Gregory Thompson MD - Internal Medicine & Brian D. O'Brien MD - Internal Medicine & Adam Husney MD - Family Medicine & Christopher G. Wood MD, FACS - Urology, Oncology
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