Pronunciation: SO-dee-um KLOD-row-nate
Common Brand Name(s): Bonefos
This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Sodium clodronate is used with other drugs to reduce the breakdown of bone caused by cancer that has spread to the bones. It is also used to treat a high level of calcium in the blood that may occur with some cancers. Sodium clodronate works by slowing bone loss and by decreasing the amount of calcium released from your bones into your blood. This medication belongs to a class of drugs called bisphosphonates.
Read the Patient Information Leaflet provided by your pharmacist before you start taking this medication and each time you get a refill. Follow the instructions very closely to make sure you absorb as much of the drug as possible and reduce the risk of injury to your esophagus. Consult your doctor or pharmacist if you have any questions.
Take this medication by mouth without food, usually 1 to 2 times a day as directed by your doctor. Take it on an empty stomach at least 1 to 2 hours before or 1 to 2 hours after eating. The timing depends on the brand you use, so follow the directions for your brand.
Take sodium clodronate with a full glass of plain water (6 to 8 ounces, 180 to 240 milliliters). Do not take it with milk or any other beverage. Swallow this medication whole. After taking this medication, stay fully upright (sitting, standing, or walking) and do not lie down for at least 30 minutes.
Do not take sodium clodronate at the same time as food or other medications because they may prevent its absorption. Take this medication 1 to 2 hours (depending on your brand) before or 1 to 2 hours after taking any products that contain aluminum, calcium, iron, magnesium, or zinc. Some examples include antacids, certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), quinapril, vitamins/minerals, dairy products (such as milk, yogurt), and calcium-enriched juice.
Drink plenty of fluids during treatment with this medication unless otherwise directed by your doctor.
The dosage is based on your medical condition and response to treatment. Do not take more of this medication than prescribed.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Keep all medical and laboratory appointments so your doctor can check the level of calcium in your blood.
Nausea or diarrhea may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including:
Medications similar to sodium clodronate may rarely cause irritation and ulcers in your stomach or esophagus. Seek immediate medical attention if any of these serious side effects occur:
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction:
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before taking sodium clodronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate); or if you have any other allergies. This product may contain inactive ingredients (such as soya lecithin from soybeans found in some brands), which can cause allergic reactions or other problems. Some people who are allergic to peanuts may also be allergic to soy. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
Some people taking sodium clodronate may have serious jawbone problems. Your doctor should check your mouth before you start this medication. Tell your dentist that you are taking this medication before you have any dental work done. To help prevent jawbone problems, have regular dental exams and learn how to keep your teeth and gums healthy. If you have jaw pain, tell your doctor and dentist right away.
Before having any surgery (especially dental procedures), tell your doctor and dentist about this medication and all other products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor or dentist may tell you to stop taking sodium clodronate before your surgery. Ask for specific instructions about stopping or starting this medication.
This medication is not recommended for use during pregnancy. Its effects on an unborn baby are not known. Consult your doctor for more details.
It is not known if this medication passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.
See also the How to Use section.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:
This medication may affect the results of certain lab tests (bone imaging tests). Make sure laboratory personnel and all your doctors know you use this drug.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center. Symptoms of overdose may include: muscle spasms, mental/mood changes.
Do not share this medication with others.
Eat well-balanced meals that contain adequate calcium and vitamin D. Consult your doctor or pharmacist for more details.
Laboratory and/or medical tests (such as calcium and other blood mineral levels, kidney and liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
If you miss a dose, take it as soon as you remember, following the dose-timing instructions in the How to Use section. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414 for additional advice on missed doses.
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016.
Copyright(c) 2016 First Databank, Inc.
Conditions of use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information in not intend to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed in indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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