See also Warning section.
This medication is used to treat a variety of serious, possibly fatal fungal infections. It works by stopping the growth of fungi.
This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This drug may also be used to reduce the risk of fungal infections in people with fevers and low white blood cell (neutrophil) counts or people with weakened immune systems (such as due to HIV, organ transplant, or cancer).
How To Use
This medication is usually given by injection into a vein as directed by your doctor, usually given once a day or every other day. It should be injected slowly over 2 to 6 hours. Your doctor may give you a smaller dose first to test your response to the medication. Dosage is based on your medical condition, weight, response to the test dose, and response to therapy. If this medication is stopped for 7 days or longer, then it should be restarted at the lowest dose and slowly increased.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
It may be necessary to continue this medication for several weeks to several months in order to treat certain infections. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition persists or worsens.
Fever, shaking, chills, flushing, loss of appetite, dizziness, nausea, vomiting, headache, shortness of breath, or fast breathing may occur 1 to 3 hours after the infusion is started. In some cases, other medications (including acetaminophen, diphenhydramine, corticosteroids such as hydrocortisone) may be necessary to prevent or relieve these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including:
- swelling/pain at injection site
- muscle/joint pain
- unusual tiredness
- muscle cramping
- signs of kidney problems (such as change in the amount of urine, painful urination)
- numbness/tingling of arms/legs
- vision changes
- hearing changes (such as ringing in the ears)
- dark urine
- severe stomach/abdominal pain
- yellowing eyes/skin
- swelling ankles/feet
- fast/slow/irregular heartbeat
- cold sweats
- blue lips
- easy bruising/bleeding
- other signs of infection (such as fever, persistent sore throat)
- mental/mood changes
- black stools
- vomit that looks like coffee grounds
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:
- itching/swelling (especially of the face/tongue/throat)
- severe dizziness
- trouble breathing
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using amphotericin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
- white blood cell (leukocyte) transfusions
- heart disease (such as irregular heartbeat, congestive heart failure)
- liver disease
- kidney disease
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include:
- anti-cancer drugs (such as mechlorethamine, nitrogen mustard)
- azole antifungals (such as ketoconazole, itraconazole)
- medications that affect the kidneys (including pentamidine, tacrolimus, aminoglycosides such as gentamicin)
- muscle relaxants (such as tubocurarine)
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center. Symptoms of overdose may include: dizziness, fainting, slow heartbeat, trouble breathing.
Laboratory and/or medical tests (such as kidney/liver function tests, potassium/magnesium levels, complete blood counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.
If you have questions about missing a dose or you don't have more medication, contact your healthcare provider or pharmacist.
Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.