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Sarcoidosis (say "sar-koy-DOH-sus") is a rare disease that creates tiny lumps of cells throughout the body. These lumps, called granulomas, are too small to see or feel. They can form anywhere on the inside or outside of the body and can cause permanent scar tissue. They often form in the lungs, lymph nodes, liver, skin, or eyes.
Sarcoidosis may affect how an organ works. For instance, if it's in your lungs, you may be short of breath. For every 10 people who get sarcoidosis, 2 or 3 will have permanent lung damage. A small number of people may end up with chronic sarcoidosis, which can last for years.footnote 1
No one can predict how sarcoidosis might affect you. Some people don't have any symptoms at all. For more than half of the people who get it, sarcoidosis appears just for a short time and then heals itself—without any treatment.
No one knows for sure what causes sarcoidosis.
Medical experts say that sarcoidosis is most likely a disease of the body's immune system.
It might also be a respiratory infection that happens when someone with certain genes comes into contact with things in the environment, like bacteria, viruses, chemicals, toxins, or allergens.
Young and middle-aged adults are the most likely to get sarcoidosis, but you can get it at any age. The disease doesn't spread from person to person.
For some people, sarcoidosis may cause no symptoms at all. For others, it can cause a variety of symptoms depending on which part of the body or which organs it affects. Some of the most common symptoms include:
Sarcoidosis may lead to lung or heart problems.
It can also cause high calcium levels in the blood (hypercalcemia). This can lead to weakness, lack of energy, loss of appetite, and other symptoms.
Sarcoidosis is often found in patients who don't have any symptoms of sarcoidosis but who have abnormal chest X-ray results.
Sometimes doctors can diagnose the disease after a physical or eye examination or by looking at a chest X-ray. Different tests like lab tests and lung tests can also help doctors make a correct diagnosis.
Your doctor may ask to take a sample of cells (biopsy) from the affected organ and examine them to make sure that the disease really is sarcoidosis. By looking at the biopsy, doctors can rule out other diseases that look like sarcoidosis.
Not everyone who has sarcoidosis needs treatment. Sometimes the disease goes away on its own. If the disease affects certain organs—such as your eyes, heart, or brain—you'll need treatment even if you don't have any symptoms.
Taking an oral corticosteroid such as prednisone is one of the most common ways to treat sarcoidosis. It works by reducing the inflammation caused by the disease.
Most people need to take prednisone for a year or more. Long-term use of prednisone, especially in high doses, can cause serious side effects. If you take prednisone, stay in close contact with your doctor to make sure that you find the lowest dose you need to control your disease.
Other medicines used to treat sarcoidosis include:
Even if you don't have any symptoms, keep seeing your doctor for ongoing care. He or she will want to check to make sure that the disease isn't damaging your organs. For example, you may need routine tests to make sure that your lungs are working well. And you should get your eyes examined regularly, even if you don't have vision problems.
Be sure to follow these steps at home:
Making lifestyle changes can help you manage your health. For example:
CitationsAmerican Lung Association (accessed July 2011). Understanding Sarcoidosis. Available online: http://www.lungusa.org/lung-disease/sarcoidosis/understanding-sarcoidosis.html.Other Works ConsultedAmerican Lung Association (accessed July 2011). Understanding Sarcoidosis. Available online: http://www.lungusa.org/lung-disease/sarcoidosis/understanding-sarcoidosis.html.Baughman RP, Lower EE (2015). Sarcoidosis. In DL Kasper et al., eds., Harrison's Principles of Internal Medicine, 19th ed., vol. 2, pp. 2205–2212. New York: McGraw-Hill Education.Foundation for Sarcoidosis Research (2005). I have sarcoidosis in my lungs, do I need to have my eyes tested? Ask the Expert Archive, July 2004–2005 Questions. Available online: http://www.stopsarcoidosis.org/sarcoidosis/faqarchive.htm.National Heart Lung and Blood Institute (2011). What Is Sarcoidosis? Available online: http://www.nhlbi.nih.gov/health/dci/Diseases/sarc/sar_whatis.html.
Current as of: February 24, 2020
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineBrian D. O'Brien MD - Internal MedicineAdam Husney MD - Family MedicineMark A. Rasmus MD - Pulmonology, Critical Care Medicine, Sleep Medicine
Current as of: February 24, 2020
Author: Healthwise Staff
Medical Review:E. Gregory Thompson MD - Internal Medicine & Brian D. O'Brien MD - Internal Medicine & Adam Husney MD - Family Medicine & Mark A. Rasmus MD - Pulmonology, Critical Care Medicine, Sleep Medicine
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