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A cold agglutinins blood test is done to check for conditions that cause the body to make certain types of antibodies called cold agglutinins. Cold agglutinins are normally made by the immune system in response to infection. They cause red blood cells to clump together (agglutinate) at low temperatures.
Healthy people generally have low levels of cold agglutinins in their blood. But lymphoma or some infections, such as mycoplasma pneumonia, can cause the level of cold agglutinins to rise.
Higher-than-normal levels of cold agglutinins generally do not cause serious problems. Sometimes, high levels of cold agglutinins can cause blood to clump in blood vessels under the skin when the skin is exposed to the cold. This causes pale skin and numbness in the hands and feet. The symptoms go away when the skin warms up. In some cases, the clumped blood cells can stop the flow of blood to the tips of the fingers, toes, ears, or nose. This is like frostbite and can cause tissue damage. In rare cases, it can cause gangrene.
Sometimes high levels of cold agglutinins can destroy red blood cells throughout the body. This condition is called autoimmune hemolytic anemia.
The cold agglutinins test may be done to:
You do not need to do anything before you have this test.
The doctor drawing blood will:
The blood sample is taken from a vein in your arm. An elastic band is wrapped around your upper arm. It may feel tight. You may feel nothing at all from the needle, or you may feel a quick sting or pinch.
There is very little chance of a problem from having a blood sample taken from a vein.
A cold agglutinins blood test is done to check for conditions that cause the body to make certain antibodies called cold agglutinins. The results of the cold agglutinins test is usually reported in titres.
The normal values listed here—called a reference range—are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what's normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.
Less than 1 to 16 (1:16) at 4 C
You may not be able to have this test or the results may not be helpful if you are taking antibiotics, especially penicillin and cephalosporins.
CitationsFischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.Other Works ConsultedChernecky CC, Berger BJ (2008). Laboratory Tests and Diagnostic Procedures, 5th ed. St. Louis: Saunders.Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.Pagana KD, Pagana TJ (2010). Mosby's Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.
Current as of: March 28, 2019
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineAnne C. Poinier MD - Internal MedicineAdam Husney MD - Family MedicineMartin J. Gabica MD - Family MedicineW. David Colby IV MSc, MD, FRCPC - Infectious Disease
Current as of: March 28, 2019
Author: Healthwise Staff
Medical Review:E. Gregory Thompson MD - Internal Medicine & Anne C. Poinier MD - Internal Medicine & Adam Husney MD - Family Medicine & Martin J. Gabica MD - Family Medicine & W. David Colby IV MSc, MD, FRCPC - Infectious Disease
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