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Blood transfusion is a medical treatment that replaces blood lost through injury, surgery, or disease. The blood goes through a tube from a bag to an intravenous (IV) catheter and into your vein.
You may need a blood transfusion if you lose too much blood, such as through:
If you have an illness in which your bone marrow doesn't make enough blood, such as aplastic anemia, you may need transfusions.
Blood used for transfusions in Canada are very safe and generally free from disease. Donated blood is carefully tested and tracked. It is very rare to get a disease through a blood transfusion.
Getting the wrong blood type by mistake is the main risk in a blood transfusion, but it is rare. For every 1 million units of blood transfused, getting the wrong blood type happens, at the most, 4 times.footnote 1 Transfusion with the wrong blood type can cause a severe reaction that may be life-threatening.footnote 2
If you have many blood transfusions, you are more likely to have problems from immune system reactions. A reaction causes your body to form antibodies that attack the new blood cells. But tests can help avoid this. Before you get a blood transfusion, your blood is tested to find out your blood type. And the blood you will get in the transfusion is tested to make sure it matches your blood.
You may have a mild allergic reaction even if you get the correct blood type. Signs of a reaction include:
A mild reaction can be scary, but it rarely is dangerous if it's treated quickly.
The most important blood type classification systems are the ABO system and the Rh system. A, B, AB, and O are the blood types in the ABO system. Each type of blood in the ABO system also has a positive or negative Rh factor. For example, if you have "A+ blood," it means your blood is type A in the ABO system and your Rh factor is positive.
If you get blood in a transfusion that isn't the right type, you may have a transfusion reaction. A mild transfusion reaction rarely is dangerous, but you must get treatment quickly. A severe transfusion reaction can be deadly.
Blood banks collect blood from volunteer donors. Before they donate, volunteers must answer questions about their current health, health history, and any diseases they may have been exposed to through travel to foreign countries, sexual behaviour, drug use, or needle sticks (such as from tattoos). Only people who pass this survey are allowed to donate blood.
Donated blood is then carefully tested for certain diseases and to find out the blood type. If there is any chance that the blood may not be safe to use, it is thrown away.
Most blood that passes the tests is then split into its components and sent out for use.
Blood and its components can be stored or used for only a short time before they must be thrown away. This is why blood banks are always looking for donors.
Transfusions are used to treat blood loss or to supply blood components that your body cannot make for itself.
Blood loss may result from injury, major surgery, or diseases that destroy red blood cells or platelets, two important blood components. If too much blood is lost (low blood volume), your body cannot maintain a proper blood pressure, which results in shock. Blood loss can also reduce the number of oxygen-carrying red blood cells in the blood, which may prevent enough oxygen from reaching the rest of the body.
Whole blood is rarely given to treat blood loss. Instead, you are given the blood component you most need. If you have lost too many red blood cells or are not making enough of them, you are given packed red blood cells. If you have low blood volume, you are given plasma and/or other fluids to maintain blood pressure. If you have lost a great deal of blood, or if your clotting factors or platelets are low or abnormal, you may also need a transfusion of either of these to help control bleeding. Sometimes you may need replacements of some blood substances if your body does not make enough of them. For example, you may be given substances to help your blood clot (clotting factors) if you do not have enough of them naturally.
Blood lost during surgery sometimes can be recovered, cleaned, and returned to you as a transfusion. This greatly reduces the amount of blood you might otherwise need to receive. Receiving your own blood back is safer, because there is no chance of a reaction.
One blood component that affects the blood's ability to clot is platelets. A reduced number of platelets (thrombocytopenia) or the failure of platelets to function properly increases the time it takes for bleeding to stop (increased bleeding time). Transfusion with platelets improves the clotting time, which reduces the risk of uncontrolled bleeding. This treatment does not cure the cause of platelet loss.
Anemia is a decrease in the number of oxygen-carrying red blood cells or a decrease in the amount of hemoglobin, the oxygen-carrying substance in the red blood cells. There are several types of anemia, each with a different cause, and each is treated differently. Severe anemia may be treated with a transfusion of packed red blood cells. This temporarily increases the number of oxygen-carrying red blood cells in circulation and may improve symptoms, but it does not treat the cause of the anemia.
Almost all of the blood used for blood transfusions is donated by volunteers.
For details on the donation process, see Donating Blood.
The process of blood donation and the handling of donated blood is regulated by Health Canada's Therapeutic Products Directorate (TPD). The TPD enforces five layers of overlapping safeguards to protect the blood supply against disease. These safeguards are implemented by Canadian Blood Services, the national organization that collects and distributes blood and blood products in all provinces and territories except Quebec. In Quebec, Héma-Québec performs this role.
Your blood is typed, or classified, according to the presence or absence of certain markers (antigens) found on red blood cells and in the plasma that allow your body to recognize blood as its own. If another blood type is introduced, your immune system recognizes it as foreign and attacks it, resulting in a transfusion reaction.
The ABO system consists of A, B, AB, and O blood types. People with type A have antibodies in the blood against type B. People with type B have antibodies in the blood against type A. People with AB have no anti-A or anti-B antibodies. People with type O have both anti-A and anti-B antibodies. People with type AB blood are called universal recipients, because they can receive any of the ABO types. People with type O blood are called universal donors, because their blood can be given to people with any of the ABO types. Mismatches with the ABO and Rh blood types are responsible for the most serious, sometimes life-threatening, transfusion reactions. But these types of reactions are rare.
For every 1 million units of blood transfused, getting the wrong blood type happens, at the most, 4 times.footnote 1 Transfusion with the wrong blood type can cause a severe reaction that may be life-threatening.footnote 2
The Rh system classifies blood as Rh-positive or Rh-negative, based on the presence or absence of Rh antibodies in the blood. People with Rh-positive blood can receive Rh-negative blood, but people with Rh-negative blood will have a transfusion reaction if they receive Rh-positive blood. Transfusion reactions caused by mismatched Rh blood types can be serious.
There are over 100 other blood subtypes. Most have little or no effect on blood transfusions, but a few of them may be the main causes of mild transfusion reactions. Mild transfusion reactions are frightening, but they are rarely life-threatening when treated quickly.
The risks of blood transfusions include transfusion reactions (immune-related reactions), non-immune reactions, and infections.
Immune-related reactions occur when your immune system attacks components of the blood being transfused or when the blood causes an allergic reaction. This is called a transfusion reaction.
Even receiving the correct blood type sometimes results in a transfusion reaction. These reactions may be mild or severe. Most mild reactions are not life-threatening when treated quickly. Even mild reactions, though, can be frightening.
Mild allergic reactions may involve itching, hives, wheezing, and fever. Severe reactions may cause anaphylactic shock.
Doctors will stop a blood transfusion if they think you are having a reaction. A reaction may turn out to be mild. But at the beginning, it is hard for doctors to know whether it will be severe.
There are several immune-related transfusion reactions.
Fluid overload is a common type of non-immune reaction.
A person can develop iron overload after having many repeated blood transfusions. This condition, sometimes called acquired hemochromatosis, is often treated with medicine. Too much iron can have an effect on many organs in the body.
The transmission of viral infections, such as hepatitis B or C or HIV, through blood transfusions has become very rare because of the safeguards enforced by Health Canada's Therapeutic Products Directorate (TPD) on the collection, testing, storage, and use of blood. The risk of infection from a blood transfusion is higher in less developed countries, where such testing may not happen and paid donors are used.
It is possible for blood to be contaminated with bacteria or parasites. Bacterial contamination can happen during or after donation. Donated blood might have a parasitic infection. Transfusion with blood that has bacteria or parasites can result in a systemic infection. But this risk is small.
The risk of a bacterial infection in donated blood is small because of the precautions taken in drawing and handling blood. There is a greater risk of bacterial infection from transfusions with platelets. Unlike most other blood components, platelets are stored at room temperature. If any bacteria are present, they will grow and cause an infection when the platelets are used for transfusion.
Before you receive a blood transfusion, your blood is tested to determine your blood type. Blood or blood components that are compatible with your blood type are ordered by the doctor. This blood may be retested in the hospital laboratory to confirm its type. A sample of your blood is then mixed with a sample of the blood you will receive to check that no problems result, such as red blood cell destruction (hemolysis) or clotting. This process of checking blood types and mixing samples of the two blood sources is called typing and crossmatching.
Before actually giving you the transfusion, a doctor or nurse will examine the label on the package of blood and compare it to your blood type as listed on your medical record. Only when all agree that this is the correct blood and that you are the correct recipient will the transfusion begin. Giving you the wrong blood type can result in a mild to serious transfusion reaction.
Sometimes a doctor will recommend that you take acetaminophen (such as Tylenol), antihistamines (such as Benadryl), or other medicines to help prevent mild reactions, like a fever or hives, from a blood transfusion. Your doctor will treat a more severe reaction if one occurs.
To receive the transfusion, you will have an intravenous (IV) catheter inserted into a vein. A tube connects the catheter to the bag containing the transfusion, which is placed higher than your body. The transfusion then flows slowly into your vein. A doctor or nurse will check you several times during the transfusion to watch for a transfusion reaction or other problem.
Experts are trying to create artificial blood or blood replacements. Blood replacements being studied include oxygen-carrying chemicals (such as perfluorocarbon emulsions) and cell-free hemoglobin—the portion of the red blood cell that carries oxygen. There are several advantages to blood replacements.
The blood replacement products being tested still have problems. For example, blood replacement products can interfere with blood tests, are more quickly removed from the body, and are less efficient oxygen carriers.
Several of these products are being developed. But their use, after they are approved, will probably be limited to emergencies involving severe blood loss caused by serious accidents.
CitationsCoil CJ, Santen SA (2011). Transfusion therapy. In JE Tintinalli, ed., Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7th ed., pp. 1493–1500. New York: McGraw-Hill.Galel SA, et al. (2009). Transfusion medicine. In JP Greer et al., eds., Wintrobe's Clinical Hematology, 12th ed., vol. 1, pp. 672–721. Philadelphia: Lippincott Williams and Wilkins.
Adaptation Date: 5/17/2023
Adapted By: Alberta Health Services
Adaptation Reviewed By: Alberta Health Services
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