Uses
This medication is used to treat a certain type of cancer of the colon (large intestine) or rectum. Panitumumab is a man-made protein (monoclonal antibody) that binds to a certain protein (epidermal growth factor receptor-EGFR). It works by slowing or stopping the growth of cancer cells.
How To Use
This medication is given by injection into a vein by a health care professional. It is usually given every 14 days or as directed by your doctor. Dosage is based on your weight and response to treatment.
Side Effects
See also Warning section.
Diarrhea, nausea, vomiting, tiredness, constipation, abdominal pain, and growth of eyelashes may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including:
- swelling ankles/feet
- unusual weakness
- irregular heartbeat
- severe muscle spasms
- mouth sores
- signs of eye problems (such as eye redness/itching/irritation, watery eyes, vision changes)
- signs of lung disease (such as cough, shortness of breath)
- menstrual changes
Prolonged and/or severe diarrhea may lead to dehydration and electrolyte imbalance. Tell your doctor right away if you develop any of the following:
- extreme thirst
- decreased urination
- dizziness
- fainting
Get medical help right away if you have any very serious side effects, including:
Rarely, panitumumab has caused very serious infusion reactions, including an allergic reaction. Get medical help right away if you develop fever, chills, or symptoms of an allergic reaction.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:
- rash
- itching/swelling (especially of the face/tongue/throat)
- severe dizziness
- trouble breathing
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before receiving panitumumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
- lung disease (such as pulmonary fibrosis, interstitial pneumonitis)
- low magnesium/calcium blood levels
Sunlight may worsen any skin reactions that may occur while you are receiving this drug. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using panitumumab. Panitumumab may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 2 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
Based on information from related drugs, this medication may pass into breast milk. Breast-feeding is not recommended while using this medication and for 2 months after the end of treatment. Consult your doctor before breast-feeding.
Drug Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center.
Notes
Lab and/or medical tests (such as magnesium/calcium levels) should be done before you start using this medication, while you are using it and for 8 weeks after completion of treatment. Keep all medical and lab appointments. Consult your doctor for more details.
Missed Dose
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.
If you have questions about missing a dose or you don't have more medication, contact your healthcare provider or pharmacist.
Storage
Not applicable. This medication is given in a clinic and will not be stored at home.
