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Atezolizumab - Injection

Pronunciation: A-te-zoe-LIZ-ue-mab

Common Brand Name(s): Tecentriq

Important: How To Use This Information

This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.


This medication is used to treat various cancers (such as liver/lung/skin cancer, alveolar soft part sarcoma - ASPS). It works by helping your immune system fight the cancer. Atezolizumab belongs to a class of drugs known as monoclonal antibodies.

How To Use

Read the Medication Guide provided by your pharmacist before you start receiving atezolizumab and each time you get a treatment. If you have any questions, ask your doctor or pharmacist.

This medication is given by a health care professional. It is injected slowly into a vein over 30 to 60 minutes as directed by your doctor. This medication may cause a serious reaction during the injection. Tell your doctor right away if you develop symptoms such as chills, flushing, or dizziness.

The dosage and treatment schedule are based on your medical condition and response to treatment. For children, the dosage is also based on weight. Your doctor may stop your treatment for some time if you get serious side effects. Your doctor may also prescribe other medications (including corticosteroids such as methylprednisolone or prednisone) to treat side effects.

To get the most benefit, do not miss any doses. To help you remember, mark the days on the calendar when you need to receive the medication.

Side Effects

See also How to Use section.

Tiredness, loss of appetite, nausea, or constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

  • signs of liver disease (such as nausea/vomiting that doesn't stop, stomach/abdominal pain, yellowing eyes/skin, dark urine)
  • new/worsening cough
  • diarrhea
  • blood/mucus in your stool
  • eye/vision problems (such as blurred vision, vision changes, eye pain)
  • headache that is severe or doesn't go away
  • stiff/painful neck
  • unusual weight gain/loss
  • mental/mood changes (such as confusion)
  • cold or heat intolerance
  • fast/slow/pounding/irregular heartbeat
  • increased thirst/urination
  • muscle weakness
  • trouble speaking
  • numbness/tingling of hands/feet/arms/legs
  • pain/redness/swelling of the arms/legs
  • signs of kidney problems (such as pink/bloody urine, change in the amount of urine, burning/painful/urgent urination)

Get medical help right away if you have any very serious side effects, including:

  • chest pain
  • seizures

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as a sore throat that doesn't go away, fever, chills).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before using atezolizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • immune system problems (such as Crohn's disease, ulcerative colitis, lupus)
  • organ transplant
  • liver disease
  • nervous system disorders (such as myasthenia gravis, Guillain-Barre syndrome)
  • infection
  • diabetes
  • heart problems (such as myocarditis)

Atezolizumab can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.

Tell your health care professional that you are using atezolizumab before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using atezolizumab. Atezolizumab may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for at least 5 months after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this drug and for at least 5 months after the last dose. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center.


Lab and/or medical tests (such as liver and thyroid function tests, chest X-ray) should be done while you are using this medication. Keep all medical and lab appointments.

Missed Dose

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.

If you have questions about missing a dose or you don't have more medication, contact your healthcare provider or pharmacist.


Not applicable. This medication is given in a hospital or clinic and will not be stored at home.

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