Top of the page
Pronunciation: eh-rith-row-MY-sin/BEN-zoh-ill per-OX-ide
Common Brand Name(s): Benzamycin
This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
This product is used to treat moderate acne. It helps to reduce the number of pimples. This medication is a combination of 2 drugs. Erythromycin works by stopping the growth of acne-causing bacteria. It belongs to a class of drugs known as macrolide antibiotics. Benzoyl peroxide also kills acne-causing bacteria and causes the top layer of skin to dry and peel off so that new skin can form. This product also contains alcohol which helps to dry extra oils from the skin.
Read the Instructions for Use if available from your pharmacist before you start using this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is for use only on the skin. Before applying, wash the affected areas thoroughly, rinse with warm water, then gently pat dry. Apply a thin layer of this medication as directed by your doctor, usually twice daily (in the morning and in the evening).
If you are using the individual pouches, you must first mix the 2 medications from the separate compartments of each pouch. Mix the contents thoroughly in the palm of your hand. Apply the product immediately after mixing.
Wash your hands after using medication. Avoid getting this medication in your eyes or inside your nose, mouth, or other mucous membranes. If this occurs, rinse thoroughly with water. Do not mix or apply medication near an open flame.
Benzoyl peroxide may bleach hair or colored fabrics (such as clothing, bedding, towels). Use caution when applying this medication near the hairline.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Do not apply large amounts of this medication, use it more often, or use it for longer than prescribed. Your condition will not improve any faster, and your risk of side effects may increase.
Acne usually improves after a few weeks of treatment. However, it may take 2 to 3 months of continued use to notice the full benefit of this product. Tell your doctor if your condition does not improve or if it worsens.
Mild dryness and mild peeling of the top layer of skin is expected. Skin irritation, itching, burning, or redness may occur, especially at the start of treatment as your body adjusts to the medication. Eye irritation and skin discoloration may also occur. If any of these effects last or get worse, stop using this product and tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Rarely, use of this medication for prolonged or repeated periods may result in other types of skin infections (such as fungal infections). Contact your doctor if you notice any unusual skin symptoms or if your condition does not improve.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using this product, tell your doctor or pharmacist if you are allergic to erythromycin or benzoyl peroxide; or to other macrolide antibiotics (such as azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
A product that may interact with this drug is:
Other skin products (such as cosmetics, medicated soaps, after-shave lotions, products containing alcohol) and other acne skin treatments may increase skin irritation, dryness, and peeling when used with erythromycin/benzoyl peroxide. Ask your doctor or pharmacist about what products are best for you, what products to avoid, and ways you can reduce skin irritation.
This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center.
Do not share this medication with others.
For best results, this medication is often used as part of a total skin care program. Follow your doctor's recommendations.
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
If you have questions about missing a dose or you don't have more medication, contact your healthcare provider or pharmacist.
If you are using the individual pouches, store them at room temperature. If you are using the premixed product in the container, store in the refrigerator. Do not freeze. Keep the container tightly closed. Discard after 3 months. This medication is flammable. Keep it away from heat and open flame. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised December 2022.
Copyright(c) 2023 First Databank, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.