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An endometrial biopsy is a way for your doctor to take a small sample of the lining of the uterus (endometrium). The sample is looked at under a microscope for abnormal cells. An endometrial biopsy helps your doctor find problems in the endometrium. It also lets your doctor check to see if your body's hormone levels that affect the endometrium are in balance.
There are several ways to do an endometrial biopsy. Your doctor may use:
An endometrial biopsy may be done to find the cause of abnormal uterine bleeding, to check for overgrowth of the lining (endometrial hyperplasia), or to check for cancer.
When a woman is having a hard time getting pregnant, an endometrial biopsy may also be done to see whether the lining of her uterus can support a pregnancy.
An endometrial biopsy is sometimes done at the same time as another test, called hysteroscopy, which allows your doctor to look through a small lighted tube at the lining of the uterus.
An endometrial biopsy is done to:
Tell your doctor if you:
Do not douche, use tampons, or use vaginal medicines for 24 hours before the biopsy. You will empty your bladder just before your biopsy.
You may want to take a pain reliever, such as ibuprofen (Advil or Motrin), 30 to 60 minutes before having the biopsy. This can help decrease any cramping pain that can be caused by the biopsy.
You will be asked to sign a consent form that says you understand the risks of the test and agree to have it done.
Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results may mean. To help you understand the importance of this test, fill out the medical test information form .
An endometrial biopsy is usually done by a gynecologist, a family doctor, or a nurse practitioner who has been trained to do the test. The sample will be looked at by a pathologist. The biopsy can be done in your doctor's office.
You will need to take off your clothes below the waist. You will be given a covering to drape around your waist. You will then lie on your back on an examination table with your feet raised and supported by foot rests (stirrups).
Your doctor will insert a lubricated tool called a speculum into your vagina. The speculum gently spreads apart the vaginal walls so your doctor can see inside the vagina and the cervix. The cervix is washed with a special solution and may be grasped and held in place with a clamp called a tenaculum.
Your cervix may be numbed with a spray or injection of local anesthetic.
The tool to collect the sample is guided through the cervix into the uterus. The tool may be moved up and down to collect the sample. Most women have some cramping during the biopsy.
An endometrial biopsy takes 5 to 15 minutes.
You may feel a sharp cramp as the tool is guided through your cervix. You may feel more cramping when the biopsy sample is collected. Most women find that the cramping feels like a really bad menstrual cramp.
Some women feel dizzy and sick to their stomachs. This is called a vasovagal reaction. This feeling will go away after the biopsy.
An endometrial biopsy usually causes some vaginal bleeding. You can use a pad for the bleeding or spotting.
There is a small chance that the cervix or uterus could be punctured during the biopsy. Bleeding or a pelvic infection is also possible.
You may feel some soreness in your vagina for a day or two. Some vaginal bleeding or discharge is normal for up to a week after a biopsy. You can use a sanitary pad for the bleeding. Do not do strenuous exercise or heavy lifting for one day after your biopsy. Do not have sex, use tampons, or douche until the spotting stops.
Follow any instructions your doctor gave you. Call your doctor if you have:
An endometrial biopsy is a way for your doctor to take a small sample of the lining of the uterus (endometrium). Lab results from a biopsy may take several days to get back.
No abnormal cells or cancer is found. For women who have menstrual cycles, the lining of the uterus is at the right stage for the time in the menstrual cycle when the biopsy was done.
A non-cancerous (benign) growth, called a polyp, is present.
Overgrowth of the lining of the uterus (endometrial hyperplasia) is present.
Cancer or cell changes that may lead to cancer are present.
For women who have menstrual cycles, the lining of the uterus is not at the right stage for the time in the menstrual cycle when the biopsy was done. More tests may be needed.
Reasons you may not be able to have the endometrial biopsy or why the results may not be helpful include:
Other Works ConsultedPagana KD, Pagana TJ (2010). Mosby's Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby.
Current as of: November 8, 2019
Author: Healthwise StaffMedical Review: Sarah Marshall MD - Family MedicineKathleen Romito MD - Family MedicineAdam Husney MD - Family MedicineMartin J. Gabica MD - Family MedicineE. Gregory Thompson MD - Internal MedicineFemi Olatunbosun MB, FRCSC - Obstetrics and Gynecology
Current as of: November 8, 2019
Author: Healthwise Staff
Medical Review:Sarah Marshall MD - Family Medicine & Kathleen Romito MD - Family Medicine & Adam Husney MD - Family Medicine & Martin J. Gabica MD - Family Medicine & E. Gregory Thompson MD - Internal Medicine & Femi Olatunbosun MB, FRCSC - Obstetrics and Gynecology
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