hepatitis B vaccine is given to protect people from
getting the infection. In response to the vaccine, the body develops antibodies
against hepatitis B virus (HBV). This response is known as active
The hepatitis B vaccine is
given as a series of 2, 3, or 4 shots (injection) in the upper arm or leg to provide
All babies need three doses:
Premature babies may need a fourth shot.
If the vaccination series is interrupted and the spacing
between doses is longer than recommended, it is not necessary to start the
series over or add more doses. The series should be completed from where it was
A two-dose series is available for teens ages 11 to
15. The time between the first and second shot should be at least 4 months.
Hepatitis B virus causes a liver
infection that can lead to serious complications, including liver cancer. It is
common in people throughout the world, particularly in Asia and sub-Saharan
The Canadian National Advisory Committee on Immunization
(NACI) recommends hepatitis B
immunization for all children. Pregnant women and
other adults who do not have immunity and who have a high chance of exposure
should be vaccinated.
Healthy babies who weigh at least
2000 g (4.4 lb) receive their
first dose of hepatitis B vaccine at 2 months or at birth either before going
home or within 12 hours of birth if the mother has hepatitis B. When a baby
receives the first dose varies by each province and territory.
Babies who are born early (premature) or who weigh less than
2000 g (4.4 lb) usually get
their first hepatitis B shot before leaving the hospital or when they are 1
month old if the mother is not infected with hepatitis B.footnote 1
When the other 2 hepatitis B shots are given to
babies depends on whether the mother has hepatitis B and the recommended
immunization schedule in the province or territory where the baby was born.
Some babies will also need hepatitis B immune globulin (HBIG). If you have
questions about your baby's immunizations, talk with your doctor.
Anyone 18 years of age or
younger who has not previously received the hepatitis B vaccine should get it.
Children adopted from countries where HBV infection is common should be tested
for hepatitis B and get shots if they are not immune.
You can keep
track of when your child received vaccines using the
National Childhood Immunization Record(What is a PDF document?).
have not received the hepatitis B vaccine series should be immunized when they
have an increased risk of exposure. Job, travel, health condition, or lifestyle
all may increase a person's risk of contracting hepatitis B.
People who live or work where there is risk of exposure include:
People who have health conditions that put them at high
risk for exposure or a severe infection include:
People whose lifestyle puts them at high risk for
For certain people, such as those with
impaired immune systems or who are at high risk of
exposure to HBV, health professionals will want to perform a blood test to make
sure the vaccine worked (post-vaccination testing).
The hepatitis B vaccine (Hep B) gives long-term (possibly lifelong) protection from hepatitis B infection.
Most people who get the vaccine do not
have any problems. But there may be soreness or tenderness where the shot was
given or mild fever for a short time.
serious allergic reactions are rare with these
vaccines, call your doctor or local health unit right away if you or your
child has trouble breathing, a high fever, or anything unusual after having the
A child who has had a severe allergic reaction to a previous
dose of hepatitis B vaccine should not get another dose of this vaccine. Tell
your doctor or nurse if your child has had a severe reaction to any vaccine or
has severe allergies.
See Drug Reference for a full list of side
effects. (Drug Reference is not available in all systems.)
If you are exposed to HBV before
you have received all three shots in the vaccination series, a dose of
hepatitis B immune globulin (HBIG) usually will
prevent infection until the vaccine takes effect.
If you have
already had hepatitis B and have developed protective antibodies to the virus,
you do not need the vaccine because you have lifetime protection (immunity)
against the infection. If you are not sure whether you have had hepatitis B,
you can be tested, or you can be vaccinated without testing. The vaccine is not
harmful for you if you are already immune.
If you have chronic HBV
infection, the vaccine will be ineffective, although it is not harmful.
The vaccine is safe for women who are pregnant or breastfeeding.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Centers for Disease Control and Prevention (2005). A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States, Recommendations of the Advisory Committee on Immunization Practices (ACIP) Part 1: Immunization of infants, children, and adolescents. MMWR, 54(RR-16): 1–23. Also available online: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5416a1.htm. [Erratum in MMWR, 55(06): 158–159. Also available online: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5506a6.htm.]
ByHealthwise StaffPrimary Medical ReviewerJohn Pope, MD - PediatricsBrian D. O'Brien, MD - Internal MedicineAdam Husney, MD - Family MedicineSpecialist Medical ReviewerWilliam Atkinson, MD, MPH - Thomas Emmett Francoeur, MD, MDCM, CSPQ, FRCPC - Pediatrics
Current as ofMay 23, 2016
Current as of:
May 23, 2016
John Pope, MD - Pediatrics
& Brian D. O'Brien, MD - Internal Medicine & Adam Husney, MD - Family Medicine & William Atkinson, MD, MPH - & Thomas Emmett Francoeur, MD, MDCM, CSPQ, FRCPC - Pediatrics
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