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Methylprednisolone/Neomycin Compound - Topical

Pronunciation: METH-ull-pred-NISS-oh-lone/nee-oh-MY-sin

Common Brand Name(s): Neo-Medrol

Important: How To Use This Information

This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.


This combination product is used to treat acne and certain other skin conditions (such as rosacea, seborrheic dermatitis). It contains a corticosteroid (methylprednisolone) that works by reducing skin swelling, redness, and itching. It also contains an antibiotic (neomycin) to help prevent skin infections. Antibiotics work by stopping the growth of bacteria. This product also contains aluminum chlorhydroxide and sulfur, which are added for their drying and peeling effects when applied to the skin.

How To Use

This product is for use on the skin only. Wash your hands before using. Avoid getting this product in your eyes or inside the mouth. If this occurs, wipe off the medication and rinse thoroughly with water.

Clean and dry the affected area as directed. Apply a small amount of medication in a thin layer on the skin and rub in gently, usually once or twice daily or as directed by your doctor. Wash your hands after use.

Do not bandage, wrap, or cover the treated area unless instructed to do so by your doctor. Do not use large amounts of this medication, apply it more often, or use it for a longer time than directed. Your condition may not improve faster, and the risk of side effects may be increased.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Tell your doctor if your condition does not improve or if it worsens after 1 week.

Side Effects

Burning, redness, irritation, dryness, or itching of the skin may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur:

  • balance/hearing changes
  • extreme/unwanted hair growth
  • "hair bumps" (folliculitis)
  • skin thinning/discoloration
  • stretch marks

Rarely, use of this medication for prolonged or repeated periods may result in fungal or bacterial skin infections. Contact your doctor if you notice any unusual skin symptoms such as scaling/swelling/hot skin.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before using this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • other skin conditions (such as eczema, psoriasis)

Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. See the doctor regularly so your child's height can be checked.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include:

  • other products for the skin (such as corticosteroids/antiseptics)


This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414. Canada residents can call a provincial poison control center.


Do not share this medication with others.

Missed Dose

If you miss a dose, apply the medication as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not apply more than the usual amount to make up for the missed dose.

If you have questions about missing a dose or you don't have more medication, contact your healthcare provider or pharmacist.


Refer to storage information from the manufacturer. If you have any questions about storage, ask your pharmacist. Protect from high heat, light, and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.