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Diabetes: How to Give Glucagon


People with diabetes sometimes get very low blood glucsoe (sugar). If they are unconscious, they need glucagon right away.

Glucagon is a hormone that raises blood glucose quickly. It can be given as a shot or as a powder that's sprayed into the nose.

If someone close to you has diabetes, you may need to give them the glucagon shot or nose spray during a low blood glucose emergency.

Learn the steps for how to give glucagon either as a shot or a nose spray. Keep the instructions with the medicine. Review the steps often, and check the expiration date on the glucagon medicine.

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Giving the shot

A glucagon kit has a syringe that contains liquid. The kit also has a bottle that contains the medicine, which is a powder.

Follow the instructions in the kit to mix the powder and the liquid. Put this mixture back into the syringe. Make sure you have the amount of glucagon that the person's doctor recommends.

Choose the injection site.

slide 1 of 6
slide 1 of 6, Choose the injection site.,

Choose a clean injection site on the buttock, upper arm, or thigh. If an alcohol swab is available, use it to clean the skin where you will give the injection.

Insert the needle.

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slide 2 of 6, Insert the needle.,

Keeping your fingers off the plunger, hold the syringe like a pencil close to the site. Then insert the needle.

Give the injection.

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slide 3 of 6, Give the injection.,

Push the plunger of the syringe all the way in so that the medicine goes into the tissue. Give the amount of glucagon that the person's doctor has recommended. Remove the needle from the skin slowly and at the same angle that you inserted it. Press an alcohol swab, if you used one, against the injection site.

Turn the head to the side.

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slide 4 of 6, Turn the head to the side.,

After giving the injection, turn the person's head to the side, to prevent choking if they vomit.

Call for emergency help.

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slide 5 of 6, Call for emergency help.,

After you give the glucagon shot, immediately call 911 or other emergency services. If emergency services have not arrived within 15 minutes and the person is still unconscious, give another glucagon shot.

Give glucose tablets or quick-sugar food.

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slide 6 of 6, Give glucose tablets or quick-sugar food.,

Give some glucose tablets or quick-sugar food such as hard candy or juice when the person is alert and able to swallow. Also give the person some long-acting source of carbohydrate such as crackers and cheese. Stay with the person until emergency help arrives.

Anytime a person who has diabetes gets glucagon, they should talk to a doctor to try to find out what caused the low blood glucose. Some causes include too much insulin, a missed meal, and insulin injected into a blood vessel. Other causes include an illness other than diabetes, liver damage, and kidney damage. Low blood glucose can also be caused by exercise or a new medicine.

Giving the nasal spray

Glucagon nasal spray is absorbed through the membranes in the nose. It doesn't have to be inhaled. It will work even if the person getting the medicine has a cold. Follow the directions with the device.

  1. Pull on the red tab, and remove the shrink wrap from the bottle.
  2. Remove the nasal spray device from the bottle. Don't push the plunger until you're ready to give the medicine.
  3. Hold the nasal spray device between your thumb and forefingers.
  4. Put the tip of the device into one nostril until your fingers touch the nose.
  5. Push the plunger firmly until it stops. This completes the dose.
  6. Turn the person on their side in case of vomiting.
  7. Call 911.

When the person is alert and able to swallow, give a quick-sugar food like glucose tablets. Juice or regular (not diet) soda pop will also work.

If the person isn't alert in 15 minutes and you have another spray device, you can give a second dose. (Each device contains one dose.) Their blood glucose should be checked for several hours after glucagon is given.


Adaptation Date: 9/11/2023

Adapted By: Alberta Health Services

Adaptation Reviewed By: Alberta Health Services

Adapted with permission from copyrighted materials from Healthwise, Incorporated (Healthwise). This information does not replace the advice of a doctor. Healthwise disclaims any warranty and is not responsible or liable for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.