Hormone therapy can be used to re-balance your body’s hormone levels in a way that feels more aligned or affirming of your gender. Hormone therapy can also promote the development of affirming body characteristics (like growing breasts or growing facial hair) as well as reduce characteristics that are not affirming or are causing dysphoria.
Your options for hormone therapy will depend on various factors that are unique to you. Many people choose to start this process by making an appointment with their primary care provider. In most cases, your primary care provider should be able to support and get a plan in place to prescribe hormone therapy if you make that decision. Your primary healthcare provider will need to have a conversation with you to make sure hormone therapy is safe and that it fits with your gender-affirming care plan.
Ultimately, the decision to start hormone therapy is yours. Your healthcare provider’s role is to encourage, guide, and assist you in making fully informed decisions. Before starting hormone therapy, it is important that you understand your treatment. Consider asking the following:
- “What effects might I expect from treatment?”
- “How long will medicines take to work on my body?”
- “What ongoing monitoring or tests are needed?”
- “Are there different ways to take hormones?”
- “What are the risks associated with treatment?”
- “Are there any expected side effects of treatment?”
It is important to consider the impact that certain medical options can have on your fertility. Changes from hormone therapy on your fertility can be permanent so it is important to talk to your healthcare provider about this.
For adults, hormone therapy can be broadly split into 2 types: estrogen-based therapy and testosterone-based therapy.
Estrogen-based therapy
Estrogen-based therapy often combines estrogen hormones and testosterone-blocking hormones. It can contribute to changes like:
Changes from estrogen-based therapy |
When you can expect the change to start after starting therapy |
How long before you’ll see the most change |
Breast growth (change is permanent and will remain even if you stop hormone therapy) |
3 to 6 months |
2 to 3 years |
Smaller testicles (change is permanent and will remain even if you stop hormone therapy) |
3 to 6 months |
2 to 3 years |
Lower fertility |
Varies |
Varies |
Redistribution of fat and potential weight gain or loss |
3 to 6 months |
2 to 5 years |
Decreased muscle mass |
3 to 6 months |
1 to 2 years |
Mood changes |
Varies |
Varies |
Fewer erections |
1 to 3 months |
3 to 6 months |
Changes to sex drive, sexual interests, or sexual function |
Varies |
Varies |
Skin changes, including softer skin and less oily skin |
1 to 6 months |
Unknown |
Less growth of body hair and facial hair |
6 to 12 months |
3 years |
Less balding (therapy will not cause hair to regrow, but may stop scalp hair loss) |
1 to 3 months |
1 to 2 years |
Estrogen-based therapy can increase your risk for some health conditions, including:
- blood clots
- pulmonary embolism (blood clot in the lung)
- stroke
- heart attack
- gallstones
Talk with your healthcare team about these risks and what to watch for.
Testosterone-based therapy
Testosterone-based therapy can contribute to changes like:
Changes from testosterone-based therapy |
When you can expect the change to start after starting therapy |
How long before you’ll see the most change |
Deeper voice (change is permanent and will remain even if you stop hormone therapy) |
3 to 12 months |
Years |
Growing body hair and facial hair (change is permanent and will remain even if you stop hormone therapy) |
3 to 6 months |
3 to 5 years |
Larger clitoris (change is permanent and will remain even if you stop hormone therapy) |
3 to 6 months |
1 to 2 years |
Scalp hair loss (change is permanent and will remain even if you stop hormone therapy) |
More than 12 months |
Varies |
Lower fertility |
Varies |
Varies |
Redistribution of fat and potential weight gain or loss |
3 to 6 months |
2 to 5 years |
Increased muscle |
6 to 12 months |
2 to 5 years |
Mood changes |
Varies |
Varies |
Changes to sex drive, sexual interests, or sexual function |
Varies |
Varies |
Skin changes, including more acne and more oily skin |
1 to 6 months |
1 to 2 years |
Vaginal dryness |
3 to 6 months |
1 to 2 years |
Stopping of menstrual period |
2 to 6 months |
Not applicable |
Testosterone-based therapy can increase your risk for some health conditions, including:
- increased red blood cells (polycythemia)
- sleep apnea
- scalp hair loss (balding)
- changes to cholesterol, which may increase your risk for heart attack or stroke
- liver inflammation
Talk with your healthcare team about these risks and what to watch for.